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S., Boks, M

AAV-AADC phase-I clinical trials demonstrated safety and a significant improvement of both motor and non-motor symptoms as assessed by the Unified Parkinson Disease Rating Scale (UPDRS), a decrease in OFF-time duration without an increased effect of ON-time dyskinesias, as well as an increase in the uptake of the AADC tracer at PET, which was used as a measure of gene expression (Christine et al

10.1016/j.clim.2015.05.014 358 ParizadehM.ArrietaM.-C

Two l of the Dpn I digested amplification product was transformed into 25 l of NEB turbo competent E.coli (NEB, C2984)

Effects, when they occur, are usually temporary and require maintenance

As mentioned above, mutation of the latter residues leads to a pronounced lowering of the MGST1 activity and mutation of the former leads to an activity decrease as well as a 67 fold increase in K m for GSH (Table 1)